ABSTRACT
Background: The elevation of troponin-T (Trop-t) and creatinine kinase myocardial isoform (Ckmb) and elevation of these markers lead to major adverse cardiac events (MACEs). The association between above-mentioned parameters along with electrocardiogram (ECG) changes can be suitable diagnostic tool for myocardial injury following percutaneous coronary intervention (PCI). The present study was attempted to know the association of the changes in surface ECG and cardiac biomarkers and MACEs following PCI with the outcome in follow up among patients in eastern India. Methods: In present study, 100 patients were randomly selected for coronary angioplasty between April2012 to March2013. All the cases were referred to catheterization laboratory for elective PCI for single vessel or multivessel in native coronary artery. The biomarkers such as trop-t and Ckmb and MACEs along with changes in ECG were estimated as per standard protocol. Results: ECG changes were statistically significantly correlated with post procedure Trop-t elevation (p<0.001), Ckmb elevation (p<0.001) and MACEs (P<0.01 and p<0.001) in 6 months followed up. Conclusion: In conclusion, the present study showed significant relationship between MACEs during followed up and changed in surface ECG along with Trop-t and Ckmb elevation in the post-PCI period of six-month followed up in stable ischaemic heart disease.
ABSTRACT
Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by a high risk of developing arterial and venous thromboembolic complications. In recent years, great insight has been gained into the understanding of the pathogenesis of thrombosis in PV. Diagnosing and managing a case of acute coronary syndrome (ACS) due to non-atherosclerotic causes is a challenge. In this case report, we share our experience in diagnosis, management and revascularization issues in non-ST-elevation myocardial infarction (NSTEMI) in a patient with polycythemia vera background.
ABSTRACT
Background: Cardiac troponin (CTnT) and creatinine kinase myocardial isoform (CKMB) are suitable marker for myocardial injury following percutaneous coronary intervention (PCI). Elevation of these markers lead to major adverse cardiac events (MACEs). The objective was to detect the elevation of serum CTnT and CKMB during post-PCI period and identify MACE during six-month followed up among patients in eastern Indian. Methods: In present study, 100 patients were randomly selected for coronary angioplasty between April2012 to March2013. All the cases were referred to catheterization laboratory for elective PCI for single vessel or multivessel in native coronary artery. The CTnT and CKMB parameters were estimated as per standard protocol. The categorization was done on the basis of baseline (normal value), ≤3time and >3time elevation for both the biomarkers and respective MACEs as MACE-1, MACE-2, MACE-3, MACE-4 and MACE-5 were determined. Results: There were more MACE in patients in six month follow up who sustainned >3times elevation in CTnT and CKMB during pos-PCI period. There was highly significant correlation (P<0.001 and P<0.01) with increasing trend of CTnT and CKMB elevation and risk of MACEs. MACEs were significantly (P<0.001 and P<0.01) correlated with diabetes mellitus, hypertension, renal dysfunction, fluoroscopy time, stent length, left ventricular ejection fraction and type of lesion. It was also observed that more hospital stay led to elevation of CTnT and CKMB. Conclusions: It is concluded that the elevation of CTnT and CKMB in serum during post-PCI can predict MACEs in six-month follow up in stable ischaemic heart disease.